Endocrine Abstracts

We have previously reported that treatment in vivo with estrogenic compounds or vitamin D metabolites increased the specific activity of creatine kinase specific activity (CK) in different organs both in intact and in ovariectomized female rats. In the present study we assessed the hormonal responsiveness of para-uterine fat from female and epididymal fat from male rats. Injection of immature female rats with 5 μg estradiol-17β (E2), 50 μg of e...

The aim: Of this study was to investigate the association between two common CTLA-4 gene SNPs (49A/G in exon 1 and CT60 A/G in 3’UTR) and Graves’ disease outcome in Lithuanian population.Methods: This case-control study was performed in the Hospital of Lithuanian University of Health Sciences. Graves’ disease patients (n=105) were divided into remission and failed treatment groups according to the final outcome of the disease. The...

3,5,3′-triiodothyronine (T3), regulates energy metabolism by oxygen consumption and thermogenesis via induction of NaK-ATPase in vivo. These changes are correlated with nuclear T3 binding in responsive organs. We showed that creatine kinase (CK) another ATP regulating enzyme, is modulated by different hormones, in tissues containing appropriate receptors. This modulation is via binding to specific receptors and changes in CK mRNA levels. Since CK is involved in en...

Introduction: Struma ovarii (SO) is a rare ovarian tumor that occurs as part of a teratoma or is found in serous or mucinous cystadenomas and consist of more than 50% thyroid tissue. More uncommon is to diagnose thyroid cancer in struma ovarii and thyroid gland of two different origins. We present a case of follicular thyroid carcinoma arising in struma ovarii of the right ovary and papillary thyroid gland carcinoma.Case: A 70-year-old woman admitted to ...

Introduction: Vaccine-induced thrombosis and thrombocytopenia (VITT) after vaccination against SARS-CoV-2 with the adenoviral vector-based vaccines ChAdOx1 and Ad26.COV2.S has been associated with adrenal pathology, such as bilateral adrenal vein thrombosis, adrenal cortex haemorrhage and adrenal insufficiency in six percent of patients1.Case report: We report the case of a 23-year-old healthy woman who presented at eight days after ChAdOx1 va...

Case History: We report the case of a 23-year-old woman who developed adrenal insufficiency secondary to bilateral adrenal haemorrhage in the context of vaccine-induced thrombosis and thrombocytopenia (VITT). She presented with breathlessness and chest pain eight days after receiving her first dose of the adenoviral vector-based ChAdOx1 vaccine. Over the course of a week, she developed fulminant VITT. Her only comorbidity was obesity, with BMI of 35 kg/m2. <p class="abstex...

Vitamin D receptors (VDRs) are expressed in bone and vascular cells which also respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis and energy metabolism measured by CK specific activity. We have previously observed that vitamin D-related compounds target several genes which affect cell proliferation, including mRNA expression of estrogen receptor (ER)α, ERβ, VDR, 1α hydroxylase of 25OHD3 (1OHase) and 12 and 15 lipoxygenas...

Objective: To analyse features of peripheral artery disease (PAD) in patients with diabetes mellitus (DM), to determine the consequences of PAD and the risk factors for amputation.Material and methods: Retrospective study of 925 diabetic patients (58% males, 95.6% with type 2 DM) with PAD treated in Vascular Surgery Centre in Vilnius City University Hospital in 1997–2011 was performed.Results: Mean age was 67.99±9.47 year...

Ovariectomy of immature female rats, results in significant decrease of trabecular bone volume and in cortical bone thickness. Previously we found that estradiol-17β (E2) restored bone structure of ovariectomized female rats (Ovx) to values obtained in intact sham-operated female rats. E2 also selectively stimulated creatine kinase specific activity (CK) a hormonal-genomic activity marker. In the present study, we compared the effects of E2</sub...

We have previously demonstrated that rat bone cells in vivo and in vitro, responded sex-specifically to gonadal steroids in stimulation of the specific activity of creatine kinase (CK). Pretreatment with vitamin D analogs upregulated the sex-specific responsiveness and sensitivity to gonadal steroids. We also found that mice cultured femoral bone marrow (BM) in the presence of dexamethasone (DEX), 1.25(OH)2D3 (1.25D) or both, differentiated into osteoblast-like c...